DHEA-S generally declines with age. The calculator uses age- and sex-specific bands, but a single result does not establish adrenal reserve or accelerated aging.
DHEA-S is the sulfated, stable storage form of DHEA, the precursor steroid from which the body manufactures both testosterone and oestrogen. It is produced almost entirely by the adrenal glands.
Levels generally decline with age, but results vary between individuals and laboratories.
Figures are micrograms per decilitre (µg/dL). The percentile labels are model anchors whose population source has not been verified; they are not laboratory reference intervals.
These curves show the calculator's model anchors, not verified population percentiles or clinical targets.
| Age | 97th | 75th | 50th | 25th |
|---|---|---|---|---|
| 20-29 | 640 | 480 | 370 | 220 |
| 30-39 | 520 | 380 | 290 | 175 |
| 40-49 | 400 | 295 | 225 | 130 |
| 50-59 | 300 | 210 | 155 | 90 |
| 60-69 | 215 | 150 | 110 | 65 |
| 70+ | 150 | 100 | 75 | 45 |
| Age | 97th | 75th | 50th | 25th |
|---|---|---|---|---|
| 20-29 | 530 | 380 | 280 | 165 |
| 30-39 | 430 | 295 | 215 | 125 |
| 40-49 | 320 | 220 | 160 | 95 |
| 50-59 | 235 | 160 | 115 | 70 |
| 60-69 | 165 | 110 | 80 | 50 |
| 70+ | 110 | 75 | 55 | 35 |
These are the exact values the Longevity Score calculator scores against, read from the engine rather than retyped, so the chart and your score cannot disagree.
The calculator scores against its own age- and sex-specific percentile anchors. Their original population source has not been verified; the bands are model inputs, not laboratory reference intervals or treatment targets.
DHEA-S helps the body produce other hormones. Interpretation depends on symptoms, age, sex, medical history, laboratory method and other test results.
The calculator's bands do not establish the cause of a result, a diagnosis or whether treatment is appropriate.
Discuss the report with a clinician, who can decide whether other tests are appropriate.
Do not start hormone supplements or alter medication based on the calculator. Evidence for anti-aging benefits from DHEA supplements in otherwise healthy adults is uncertain.
See where you sit across all 8 dialsThe calculator scores against its own age- and sex-specific percentile anchors. Their original population source has not been verified; the bands are model inputs, not laboratory reference intervals or treatment targets.
What DHEA-S measures and what moves it · Free testosterone — downstream of DHEA-S · The hormonal dial
Choose a question. Answers come from this site, and nothing you open is sent anywhere.
The calculator scores against its own age- and sex-specific percentile anchors. Their original population source has not been verified; the bands are model inputs, not laboratory reference intervals or treatment targets.
Chronological age counts birthdays. Biological age estimates how old your body appears to be functioning, based on measurable biomarkers. Two people born the same year can differ by a decade or more in vascular stiffness, insulin signalling or cardiorespiratory fitness. Biological age makes that gap explicit — and unlike your birthday, it can move in either direction.
Each biomarker you enter is scored against longevity-optimised reference ranges and grouped into one of eight dials. Every dial produces its own biological age, and those are combined using fixed weights into a single composite, then expressed as a Longevity Score from 0 to 100. The weighting reflects how strongly each system predicts healthspan: structural and vascular carry the most, hormonal the least.
No. The short form contains a subset of scoring inputs plus context-only fields, and you can leave any of them blank. It is not a recommendation to obtain tests. Missing values are excluded from the calculation — never treated as zero or as 'normal'. A dial with no scored data is dropped entirely and the remaining weights renormalise.
Some inputs can be measured without bloodwork. Blood pressure needs a home cuff and waist-to-height needs a tape measure. Wearable estimates vary; the floor-based sitting-rising test carries a fall risk and should only be attempted if safe.
Both terms describe what this tool does, and which one fits depends on what you are asking. "Anti-aging" is the term most people search, and loosely means anything aimed at slowing or reversing age-related decline — this tool fits that description if you score your dials and act on what you find. "Healthspan calculator" is the more precise term: healthspan is the number of years lived without serious chronic disease or disability, and that cannot be measured directly, so this tool scores eight systems that each function as an early-warning proxy for it. Either way, the method is the same: real biomarkers, published thresholds, no vanity-metric framing.
Several popular tools ask only about habits — exercise days, sleep hours, smoking, diet quality — and return a single precise-looking age. We looked at the research behind that approach and chose not to build it. Published studies do show real, individually-measured links between specific habits and epigenetic age acceleration, but those effect sizes come from different study populations, different DNA-methylation clocks and different measurement units. Adding them together into one number is not something the underlying research actually supports — it produces a precise-looking result built on an imprecise method. Our dials use direct physiological measurements instead: a real blood pressure reading, a real VO₂ max, a real ApoB value. Several dials score from home-measurable data alone with no quiz-guessing involved — see what you can measure without a blood test, above.
Standard reference ranges describe what is common in a general population, which now includes a great deal of metabolic dysfunction. They are tuned to flag disease, not to identify what is optimal for a long healthspan. A fasting insulin of 20 µIU/mL sits inside most labs' normal range and is strongly associated with insulin resistance. This tool uses longevity-optimised thresholds instead, so a flag here means room for optimisation — not a diagnosis.
For understanding a single result, do — a frontier chat model is genuinely good at that, often clearer than most medical sites, and it handles markers no fixed tool covers. The limitation is different from the one most people assume. A language model produces a plausible response rather than a computed one, so the same panel can score differently on different days. That is fine when exploring an idea and disqualifying when measuring change, because you cannot tell how much of a difference is you and how much is the method. Use both: a chat model to understand, a fixed instrument to track.
Biomarker values, assessment history and visit-preparation drafts are stored in your browser. The visit draft is separate from assessment exports and share links; copying or printing it can leave a copy outside the browser. There are no user accounts or third-party tracking. We keep anonymous usage totals on our own server, such as how many people reached a results screen on a given day; browsers sending Do Not Track or Global Privacy Control are not counted. Optional lab-report upload and AI coach features send data to Anthropic. Optional retest reminders send an email address, date and reminder label to our service and email provider. See our privacy policy for details.